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使用新辅助疗法与激进前列腺切除术的组合方法,以改善高风险前列腺癌的瘤结果:叙述性审查
Keita Nakane1, Makoto Kawase1, Daiki Kato1
1Department of Urology, Graduate School of Medicine, Gifu University, Yanagido, Gifu, Japan.
Translational cancer research
|August 15, 2024
概括
在前列腺切除术前用于高风险前列腺癌 (PCa) 的新辅助激素治疗 (NHT) 并没有改善瘤结果. 组合疗法显示出潜力,但需要进一步研究个性化治疗策略.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 前列腺癌 (PCa) 是男性最常见的癌症,高风险病例具有显著的死亡风险.
- 对高风险的PCa,尤其是放射治疗时,雄激素剥夺疗法 (ADT) 是至关重要的.
- 在急性前列腺切除术 (RP) 之前,对于高风险的PCa,新辅助疗法的作用仍在争论中.
研究的目的:
- 审查高风险PCa的RP的瘤结果.
- 评估RP之前的新辅助疗法 (NHT和NCHT) 的意义.
- 强调高风险PCa的管理策略.
主要方法:
- 在PubMed和Scopus数据库的文献搜索 (2005-2023年).
- 关键词:前列腺癌,前列腺切除术,放射治疗,新辅助疗法,治疗结果.
- 在RP之前对新辅助激素疗法 (NHT) 和新辅助化学激素疗法 (NCHT) 的研究的综述.
主要成果:
- 在RP之前的NHT减少了不良的病理特征,但没有显著改善生物化学复发 (BCR).
- 纳税素的新辅助化学激素疗法 (NCHT) 显示出可接受的益处,并改善了无BCR的生存率.
- 与ADT和雄激素受体信号抑制剂 (ARSI) 的联合治疗产生了不同的结果.
结论:
- 不建议单独使用NHT来降低或减少高风险PCa的积极外科边缘 (PSM).
- 与ARSI结合的NHT可能比单独的RP提供瘤益处,但结果不一致.
- 需要个性化治疗策略来管理高风险的PCa.
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