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在非功能性上腺偶发性瘤中,糖尿病患者和没有糖尿病患者之间的血类固醇分析
Yui Nakano1, Maki Yokomoto-Umakoshi1, Kohta Nakatani2
1Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Journal of the Endocrine Society
|August 15, 2024
概括
非功能性上腺意外瘤 (NFAI) 与糖尿病相关. 在患有NFAI的男性中,较高的11β-基丸激素水平与高血糖症和胰腺β细胞功能障碍相关,独立于皮质醇.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 类固醇生物化学 类固醇生物化学
背景情况:
- 上腺瘤 (AI),包括非功能上腺瘤 (NFAI),在糖尿病患者中经常观察到.
- 虽然NFAI诊断排除了明显的荷尔蒙过量,微妙的皮质醇过分分泌或其他类固醇代谢物的参与DM病变发生的情况尚不清楚.
- 在NFAI患者中调查类固醇概况可能会阐明将上腺功能与代谢功能障碍联系起来的新机制.
研究的目的:
- 在被诊断为非功能性上腺瘤 (NFAI) 的患者中,研究血类固醇代谢物和糖尿病 (DM) 之间的关联.
- 确定特定的类固醇配置文件,以区分患有和没有DM的NFAI患者.
主要方法:
- 68名NFAI患者 (31名男性,37名女性) 的血样本使用液态染色学-并联质谱分析了22种类固醇代谢物.
- 数据根据年龄进行了调整,并使用差别分析和贝叶斯内核机器回归分析.
- 德克萨米他抑制测试后的血清皮质醇水平被用作调整的混剂.
主要成果:
- 血类固醇样本在患有DM和没有DM的男性之间有显著的歧视,但在女性中没有.
- 11β-基测试,一种上腺衍生的雌激素,在患有DM的男性中显著高,是主要的歧视因素.
- 11β-基测试与禁食血葡萄糖和HbA1c呈正相关性,与胰腺β细胞功能 (HOMA2-B) 呈负相关性,独立于皮质醇水平.
结论:
- 在NFAI患者中,患有和没有DM的男性之间,血类固醇的形状不同.
- 在患有NFAI的男性中,增加的11β-基丸激素与高血糖症和胰腺β细胞功能受损有关,这表明在DM发展中除了皮质醇之外还有其作用.
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