由于使用商业性能增强补充剂使用,可逆性妇产和阴性腺
Serena Chong1, Catherine A Woolnough2, Sundar R Koyyalamudi3
1Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales 2050, Australia.
JCEM case reports
|August 15, 2024
概括
商用补充剂可能含有禁止的增强性能的药物 (PED) 和激素. 一名食用这些补充剂的男子出现了荷尔蒙异常,在停止使用后,这些异常得到解决,突出了补充剂的风险.
科学领域:
- 内分泌学 在内分泌学.
- 运动医学 运动医学
- 临床毒理学 临床毒理学
背景情况:
- 提高表现的补充剂 (PES) 被广泛使用,但可能含有未披露的禁止提高表现的药物 (PED) 和激素.
- PES与合成代谢剂和其他物质的污染可能导致不良健康结果.
- 荷尔蒙异常和阴性腺是摄入受污染的PES的潜在后果.
研究的目的:
- 报告一个男性使用PES的阴性腺和妇产不良症病例.
- 确定消费的PES中存在的特定禁用物质和激素.
- 为了证明这些不良影响在停止使用PES时是可逆的.
主要方法:
- 一个40岁男性的病例介绍,他患有妇产不良和阴道腺不良症.
- 使用体外和液体染色体质谱仪分析商业上可用的PES,用于禁止的PED (RAD-140,MK-677,卡达林) 和激素 (,雌激素,GH).
- 在停止PES之前和之后,对患者的症状和激素水平进行临床监测.
主要成果:
- 这位患者出现了双边性妇产不适症和生化性低阴性高阴性低阴性.
- 发现PES含有RAD-140,MK-677,卡达林,,雌激醇和GH.
- 停止PES导致症状完全消失,并使性性性性性性的正常化.
结论:
- 商用PES可能是未申报的PED和类固醇激素的来源.
- 消费受污染的PES可能会导致显著的荷尔蒙异常和临床表现.
- 临床医生应该考虑PES作为患者内分泌功能障碍的潜在原因.
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