压力和物质使用障碍:风险,复发和治疗结果
1The Yale Stress Center, Yale School of Medicine, Department of Psychiatry, New Haven, Connecticut, USA
The Journal of clinical investigation
|August 15, 2024
概括
压力通过破坏适应性应激反应,显著影响物质使用障碍 (SUDs). 了解这些干扰是开发成有效治疗和预防复发的关键.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 成研究 研究成研究
背景情况:
- 压力是滥用物质和物质使用障碍 (SUD) 的已知危险因素.
- 最近的研究集中在将压力与SUD联系在一起的复杂机制上.
- 适应性应激反应框架对于理解这些联系至关重要.
研究的目的:
- 引入一个多层次的"适应性应激反应"框架.
- 审查关于慢性压力,创伤和药物使用如何破坏这种反应的证据.
- 讨论对预防和治疗成的影响.
主要方法:
- 这是一篇综述性文章,综合了现有研究.
- 它检查了主观,认知,外围和神经生物学领域的证据.
- 该框架考虑了压力基线,急性反应和恢复阶段.
主要成果:
- 适应性应激反应受到慢性压力因素,创伤和药物滥用的干扰.
- 这些干扰在多个领域表现出来,影响应对能力,渴望和复发风险.
- 改变的应激反应导致不灵活的应对能力和持续的药物摄入.
结论:
- 针对"成的压力病理生理学"为干预提供了有希望的途径.
- 干预措施可以旨在减轻与压力相关的药物动机变化.
- 通过解决与压力相关的因素来改善SUD治疗结果是关键目标.
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