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Updated: Jun 16, 2025

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases
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Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases

Published on: September 6, 2024

325

用小分子激活蛋白质酸酶5的化激活

Qiuyue Zhang1,2, Ling Yan1,2, Lixiao Zhang1,2

  • 1Jiangsu State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

Journal of medicinal chemistry
|August 15, 2024
PubMed
概括

研究人员发现了DDO-3733,一种新型的蛋白质酸酶5 (PP5) 的全激活剂. 这种化合物绕过了PP5的自我抑制,促进了脱酸化,并减少了由HSP90抑制剂引起的热冲击反应.

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