肠道屏障作为结直肠癌治疗中的守门员
Roy Hajjar1,2,3,4,5, Carole Richard2,3,5, Manuela M Santos1,4,6
1Nutrition and Microbiome Laboratory, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
结肠直肠癌手术可以削弱肠道屏障,允许细菌扩散. 恢复肠道屏障功能可能会改善愈合并减少癌细胞的扩散,从而有可能改善患者的生存率.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,尽管查工作仍存在高发病率.
- 手术切除是CRC的主要治疗方法,但往往会导致术后并发症.
- 这些并发症包括肠道屏障功能受损和细菌产品如脂多糖的转移,引发炎症.
研究的目的:
- 探索肠道微生物群和微生物代谢物在调节肠道炎症和外科治疗中的作用.
- 调查手术后在CRC患者中恢复肠道屏障完整性的研究.
- 评估肠道屏障功能对CRC细胞扩散和结肠外转移的影响.
主要方法:
- 对肠道微生物群,炎症和结直肠癌手术结果的当前文献的综述.
- 分析微生物代谢物影响肠道屏障功能和愈合的机制.
- 讨论肠道屏障完整性与癌细胞扩散之间的关系.
主要成果:
- 肠道微生物群及其代谢物显著影响基本肠道炎症和术后愈合过程.
- 手术后肠道屏障功能受损与细菌转移和炎症加剧有关.
- 恢复肠道屏障完整性可能会抑制结肠直肠癌细胞的扩散和植入.
结论:
- 肠道微生物群在调节炎症和在结直肠癌手术后促进肠道愈合方面发挥着至关重要的作用.
- 增强肠道屏障功能是一种潜在的治疗策略,可以缓解手术后并发症并改善CRC患者的存活率.
- 对微生物向干预的进一步研究可以优化手术结果,减少结直肠癌转移性复发.
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