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儿童艾滋病毒肝炎同时感染:治疗和预防的进展
Chiara Rubino1, Mariangela Stinco1, Giuseppe Indolfi1,2
1Hepatology Unit, Meyer Children's Hospital IRCCS.
Current opinion in HIV and AIDS
|August 15, 2024
概括
患有艾滋病毒的儿童同时感染肝炎会加快肝病的发展. 早期查,监测和特定治疗,如HBV的ART和HCV的DAA,对于更好的结果至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 肝病学 肝病学是一种肝病学.
- 肝炎和艾滋病毒同时感染
背景情况:
- 病毒性肝炎的共同感染是艾滋病毒感染者 (PLHIV) 面临的重大全球健康挑战.
- 共同的传播途径,特别是在高度流行地区,增加了共感染的风险.
- 同时感染可以加剧肝病的进展,增加死亡率,即使有效的抗逆转录病毒疗法 (ART).
研究的目的:
- 审查当前的证据和建议,以管理艾滋病毒感染儿童的肝炎联合感染.
- 突出病毒性肝炎对艾滋病毒感染儿童肝病的影响.
- 为临床实践提供有关查,监测和治疗策略的信息.
主要方法:
- 对联合感染儿童肝病自然史的现有数据进行系统分析.
- 对携带艾滋病毒和乙型肝炎病毒 (HBV) 或乙型肝炎病毒 (HCV) 联合感染的儿童的治疗策略的审查.
- 对这一群体病毒性肝炎的管理和预防的证据的评估.
主要成果:
- 病毒性肝炎的同时感染会加速肝病的进展,并增加艾滋病毒感染儿童的发病率和死亡率.
- 患有HIV-HBV同时感染的儿童需要使用对两种病毒都有效的药物进行ART.
- 患有HIV-HCV同时感染的儿童可以从直接作用的抗病毒药物 (DAA) 中获益,以消除HCV.
结论:
- 对于包括儿童在内的PLHIV病毒性肝炎的常规查至关重要.
- 密切监测肝病进展和并发症是必要的,同时感染的儿童.
- 实施全面的预防策略以减少HBV和HCV的传播至关重要,特别是在流行地区.
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