在狗模型中,左心室隔膜节奏的心室激活模式
Feiyu Wei1, Xiaohui Kuang1, Xi Zhang1
1Department of Cardiology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, 650032, Kunming, Yunnan Province, People's Republic of China.
概括
左心室隔膜节拍 (LVSP) 和左束枝节拍 (LBBP) 显示出类似的心室激活模式. 由于其可比的电同步和捕获左捆分支的能力,LVSP为生理节奏提供了潜在的替代方案.
科学领域:
- 心血管电生理学 心血管电生理学
- 心脏节拍是因为心脏节拍.
- 对心肌激活的比较
背景情况:
- 左捆枝节奏 (LBBP) 是一种成熟的生理节奏方法.
- 左心室隔膜节奏 (LVSP) 表现出与LBBP相似的QRS形态,需要对其激活模式进行进一步调查.
- 了解心室激活对于优化节奏策略至关重要.
研究的目的:
- 阐明和比较LVSP和LBBP之间的心室激活模式.
- 调查LVSP作为生理节奏技术的可行性.
主要方法:
- 通过跨腹腔隔膜利用犬类模型对LBBP和LVSP进行检测.
- 采用心内回声,心电图和多个电极导管进行记录.
- 隔离和染色的心脏,以确认步伐领先位置.
主要成果:
- LVSP同时从顶部和底部区域激活了左侧的His-Purkinje系统,而LBBP的激活则从顶部进行.
- 左心室隔膜心肌激活发生在两个节奏组的apically到 basically.
- 左心室内电同步在LVSP和LBBP之间是可比的 (46.7±1.8毫秒对45.0±1.4毫秒).
结论:
- 对于LVSP和LBBP,心室激活序列是相似的.
- LVSP证明了捕获左捆分支的潜力,支持其临床适用性.
- 这些发现为在临床环境中探索LVSP提供了理由.
相关概念视频
The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Heart Sounds
Heart sounds are generated by the turbulence in blood flow due to the closing of heart valves. These sounds are best perceived slightly away from the valves, where the blood flow disseminates the sound.
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Physiology of the Heart: The Cardiac Cycle
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...


