由于无机引起的老鼠脏的形态和功能变化
Pavle Randjelović1, Niko Radulović2, Nikola Stojanović1
11Department of Physiology, Faculty of Medicine, University of Niš, Niš, Serbia.
Acta veterinaria Hungarica
|August 15, 2024
概括
在老鼠中短期的无机 (Se) 显示出轻微的效应,包括扩大的管道和质细胞,但在高剂量时相对安全. 这表明在特定的健康场景中可能有好处.
科学领域:
- 毒理学 毒理学 毒理学
- 微量元素的新陈代谢
- 脏生理学 脏生理学
背景情况:
- (Se) 是一种微量元素,具有狭窄的治疗指数.
- 它表现出双重作用,根据度,作为氧化剂和抗氧化剂.
- 了解特定形式的的安全性,如无机,对于治疗应用至关重要.
研究的目的:
- 研究无机对功能和结构的安全性和潜在副作用.
- 评估无机Se的超治疗剂量对大鼠脏的影响.
- 为了确定安全的短期无机Se应用的门.
主要方法:
- 在超治疗剂量中给大鼠服用无机8天.
- 评估脏组织的微观变化和氧化应激.
- 测量血尿素和肌素水平以评估功能.
- 分析脏形态测量,专注于近端管道和球体.
主要成果:
- 在脏组织中没有检测到微观变化或氧化应激.
- 血尿素和肌素的适度增加表明功能略有下降.
- 观察到显著的形态变化,包括扩大的近端管道和球粒.
- 短期无机Se诱导了轻微的功能和超结构性脏变化.
结论:
- 在短时间内以超治疗剂量给予无机Se,在老鼠中引起了轻微的脏改变.
- 观察到的变化是功能性的和超结构性的,没有明显的毒性.
- 当Se的益处超过潜在风险时,无机Se在短期使用中可能相对安全,例如在暴露于毒剂或高氧化应激的情况下.
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