在精神分裂症患者的益生菌治疗
Robert W Buchanan1, Anne E Werkheiser2, Hanna Michel1
1From the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD.
Journal of clinical psychopharmacology
|August 15, 2024
概括
这项研究发现,富含橄果糖的胰岛素 (OEI) 增加了精神分裂症患者的丁酸盐水平. 这种益生菌干预措施在这个人群中显示出对肠道健康的前景.
科学领域:
- 微生物组研究的研究.
- 营养精神病学是一种精神病学.
- 胃肠病学 胃肠病学
背景情况:
- 精神分裂症与产生丁酸盐的肠道细菌水平较低有关.
- 丁酸盐对于肠道屏障的完整性至关重要,并具有抗炎性质.
- 这项研究调查了益生菌是否可以促进丁酸盐的产生.
研究的目的:
- 为了确定富含橄果糖的胰岛素 (OEI) 是否会增加精神分裂症患者的丁酸盐水平.
- 在受控试验中评估特定益生菌 (Prebiotin) 的疗效.
主要方法:
- 这是一项为期10天的双盲,安慰剂受控随机试验,涉及27名精神分裂症或精神分裂情绪障碍患者.
- 参与者接受了OEI (4g,每天3次) 或安慰剂 (马尔托德克斯).
- 在OEI挑战之前和之后测量了血甲基酸盐水平,以评估治疗效果.
主要成果:
- 与安慰剂相比,OEI组中的更多参与者满足了挑战响应标准.
- OEI治疗导致基线丁酸盐水平增加 (效果大小为0.58).
结论:
- 益生菌OEI在精神分裂症患者中选择性地提高了血丁酸盐水平.
- 这项概念验证研究证明了通过肠道微生物群调节来实现潜在的治疗途径.
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