唾液素检测喉回流:它会改变我们的管理吗?
Jinrang Li1,2, Jacqueline Allen3
1Department of Otolaryngology Head Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital.
唾液素检测显示出对非侵入性诊断喉回流 (LPR) 的承诺. 素测试也可以帮助预测对质子抑制剂 (PPI) 的治疗反应,指导个性化LPR治疗.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 诊断医学 诊断医学
背景情况:
- 喉回流 (LPR) 的诊断仍然具有挑战性.
- 目前对LPR的诊断方法可能具有侵入性或缺乏特异性.
- 素是一种消化酶,是上空消化道中反流体暴露的潜在生物标志物.
研究的目的:
- 审查唾液和喉组织素测量的临床实用性,用于诊断和管理LPR.
- 评估素检测作为LPR的非侵入性诊断工具.
- 探索素测量在预测治疗反应中的作用.
主要方法:
- 对现有关于用于LPR的唾液和组织pepsin检测的文献的审查.
- 分析了研究研究素水平和LPR诊断之间的相关性.
- 对素阳性和对质子抑制剂 (PPI) 治疗反应的研究进行审查.
主要成果:
- 唾液素检测提供了一种非侵入性的方法来识别LPR.
- 素测试方法,样品时间和数量仍然是可变的和有争议的.
- 素阳性与改善对PPI治疗的反应相关,这表明它在指导治疗中的作用.
- 在喉组织中检测素具有与唾液检测相似的临床价值,因此需要进一步研究.
结论:
- 在口腔喉中检测唾液素显示出非侵入性LPR诊断的潜力,尽管最佳方法和诊断值需要澄清.
- 无论是基于唾液还是基于组织的素检测,都可能有助于预测PPI的有效性和个性化LPR治疗.
- 唾液素的最佳检测门和采样策略需要进一步标准化,并且可能在地理位置上有所不同.
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