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印度尔-3-化物通过增加肠干细胞扩张来缓解高脂肪饮食引起的肠壁障碍

Jiaqi Zhang^1,2, Ruofan Zhang^1,2,3, Yahui Chen^1,2

¹Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Journal of agricultural and food chemistry

|August 15, 2024

概括

补充印醇-3-化物 (IAld) 可减轻高脂肪饮食 (HFD) 诱导的肠道屏障破坏. IAld通过烯碳化合物受体 (AHRs) 促进肠道干细胞的增殖,恢复肠道平衡.

科学领域:

胃肠病学胃肠病学
代谢性疾病代谢性疾病
免疫学免疫学免疫学

背景情况:

高脂肪饮食 (HFD) 破坏肠道屏障,导致炎症.
印度醇-3-化物 (IAld) 显示出管理炎症反应和肠道健康的潜力.
在HFD引起的肠道问题中IAld的具体作用尚未完全理解.

研究的目的:

为了研究IAld对HFD诱导的肠道屏障破坏的影响.
确定IAld是否可以改善与HFD相关的代谢障碍和炎症.
阐明IAld影响肠道屏障功能的机制.

主要方法:

给小鼠吃的是正常食 (NCD) 或HFD,一些HFD组接受IAld (200或600毫克/公斤).
评估了代谢参数,肠道透性和全身炎症.
评估了IAld对肠干细胞 (ISC) 增殖和酸受体 (AHR) 激活的影响.

主要成果:

补充IAld可降低HFD养小鼠的脂肪积累和代谢功能障碍.
它降低了肠道的通透性,导致系统性炎症减少.
通过通过AHR激活促进ISC增殖,IAld增强了肠道屏障功能.

结论:

饮食IAld可以改善HFD引起的代谢障碍和肠道屏障缺陷.
通过激活AHR介导的ISC增殖,IAld可以恢复肠道平衡.
IAld代表了与HFD相关的肠道健康问题的潜在治疗策略.

关键词:

有高脂肪的饮食.印度尔-3-化物肠道屏障的破坏肠道屏障的破坏肠道干细胞是什么?肠道干细胞是什么?

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