24小时血压水平和变异性的纵向变化与认知能力下降的关联
Jesus D Melgarejo1,2,3, Kristina P Vatcheva1,4, Silvia Mejia-Arango1,2
1Institute of Neuroscience, Neuro and Behavioral Health Integrated Unit, School of Medicine, University of Texas Rio Grande Valley, Harlingen.
Journal of hypertension
|August 15, 2024
概括
较高的24小时血压变化,而不是它的水平,与认知能力下降有关. 门诊血压监测可以帮助识别痴呆和阿尔茨海默病的风险.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 高办公室血压 (BP) 是认知能力下降的已知危险因素.
- 关于24小时门诊血压监测与认知能力下降之间的联系的证据有限.
- 没有研究研究了24小时BP纵向变化的对认知衰退的影响.
研究的目的:
- 为了确定24小时门诊血压测量的纵向变化是否与认知能力下降有关.
- 为了研究血压变化和随时间推移的认知功能之间的关系.
- 探索 ambulatory BP 监测认知障碍的预测价值.
主要方法:
- 包括马拉卡伊博老龄化研究中的437名没有痴呆症的参与者.
- 关于24小时门诊血压监测和认知功能 (SRT和MMSE) 的前性数据收集.
- 多变量线性混合回归模型分析BP变化和认知衰退之间的关联.
主要成果:
- 24小时血压水平的纵向变化与认知功能没有显著相关 (P ≥0.09).
- 增加的24小时和白天血压变化与SRT延迟回忆得分的下降相关.
- 在随访期间,夜间高血压变化与MMSE得分的下降有关.
结论:
- 较高的24小时血压变化,独立于血压水平,与认知能力下降有关.
- 24小时门诊血压监测可能有助于早期识别和降低痴呆和阿尔茨海默病风险的策略.
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