解锁心肠连接:人类微生物群对认知的影响
Anna Castells-Nobau1, Jordi Mayneris-Perxachs2, José Manuel Fernández-Real3
1Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta Hospital, Girona, Spain; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain; CIBER Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain; Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain.
Cell host & microbe
|August 15, 2024
概括
肠道微生物群通过与大脑的复杂相互作用影响认知功能. 准肠道微生物组为增强认知健康和弹性提供了有希望的策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢性疾病研究研究
背景情况:
- 肠道微生物群,包括细菌,菌体和真核生物,在人类健康中起着至关重要的作用.
- 肠道微生物组成和功能的变化越来越多地与认知过程有关.
- 代谢性疾病的局面受到肠道微生物组失调的影响,可能会影响大脑健康.
研究的目的:
- 探索肠道微生物群对健康个体和代谢疾病患者认知功能的影响.
- 阐明微生物群-肠-大脑相互作用背后的机制.
- 审查针对肠道微生物群的治疗策略,以提高认知健康.
主要方法:
- 关于肠道微生物群和认知功能的当前科学文献的综述.
- 分析连接微生物组件 (细菌,细菌菌体,真核生物) 和功能与中枢神经系统的机制.
- 检查旨在调节肠道微生物组以获得认知益处的干预措施.
主要成果:
- 肠道微生物群的组成和功能显著影响认知过程.
- 微生物群-肠-大脑轴涉及复杂的双向通信通道.
- 新出现的证据支持细菌菌体和真核生物在这些相互作用中的作用,超越了细菌.
结论:
- 了解微生物组-大脑轴对于促进认知健康至关重要.
- 有针对性的肠道微生物群干预显示出促进认知性和预防认知障碍的潜力.
- 对微生物功能和各种微生物成分的进一步研究是有必要的.
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