人体皮肤的引导波弹性学,采用一个分层模型,结合了肌肉状态的影响
Shiyu Ma1, Zhaoyi Zhang1, Guo-Yang Li2
1Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, PR China.
Journal of biomechanics
|August 15, 2024
概括
这项研究引入了一种新的引导波弹性学方法,用于在体内测量单个皮肤层的机械性能. 这种技术可以解释肌肉状态,提高皮肤衰老和疾病研究的准确性.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 生物力学 生物力学
背景情况:
- 在体内皮肤的机械表征对于了解衰老,疾病和治疗疗效至关重要.
- 在体内测量个体皮肤层的特性仍然是一个重大的挑战,因为皮肤的复杂的层次结构.
研究的目的:
- 开发和验证引导波弹性学方法,用于体内层次人类皮肤的机械表征.
- 为了纳入基础肌肉状态对皮肤机械性质的影响.
主要方法:
- 利用有限元模拟和幻影实验来验证引导波弹性学技术.
- 在健康受试者身上进行了体内实验,以评估该方法的临床适用性.
- 开发了一个相位图来说明肌肉状态对弹性模量测量的影响.
主要成果:
- 该方法实现了高精度,在皮肤模仿幻影中,剪切模量识别的误差不超过11%.
- 统计分析证实,肌肉收缩显著地使皮肤变硬 (p < 0.001).
- 阶段图通过详细说明肌肉状态影响,为实际应用提供指导.
结论:
- 引导波弹性图法提供了一个有前途的方法,用于非侵入性,体内评估个体皮肤层机制.
- 考虑到肌肉状态对于准确的体内皮肤机械性质测量至关重要.
- 这种技术在临床诊断和评估皮肤病治疗中具有潜在的应用.
相关概念视频
Introduction to the Integumentary System
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Accessory Structures of the Skin: Hair and Hair Follicles
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Model Approaches for Pharmacokinetic Data: Physiological Models
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...


