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JNK和Hippo通路控制上皮质完整性,并通过调节重叠的转录基因组来预防瘤发作

Katrina A Mitchell¹, Joseph H A Vissers², Jonathan M Pojer¹

¹Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.

Current biology : CB

|August 15, 2024

概括

表皮器官通过去除缺陷细胞来预防瘤. 通过AP-1/CtBP和Yorkie/Scalloped转录因子,Jun-N-终端激酶 (JNK) 和Hippo通路协调基因抑制以保持组织完整性和抑制瘤生长.

科学领域:

细胞生物学细胞生物学
发展生物学发展生物学
癌症生物学癌症生物学

背景情况:

表皮器官拥有消除受损细胞的机制,防止瘤形成.
细胞中基极性丧失可以导致瘤转变.
像Jun-N-终端激酶 (JNK) 和Hippo这样的信号通路在细胞平衡中起着至关重要的作用.

研究的目的:

阐明JNK和Hippo通路调节上皮质完整性的分子机制.
确定转录因子和向基因参与预防瘤开始.
了解如何识别和去除有缺陷的细胞以维持器官平衡.

主要方法:

在Drosophila melanogaster眼睛影像盘中进行的有针对性的DamID实验.
对转录因子结合和基因表达的分析.
调查AP-1,Hippo路径组件 (约克,贝) 和CtBP之间的相互作用.

主要成果:

(AP-1) 和河马通路调节者 (约克,贝) 结合重叠的基因组促进器官生长.
在瘤细胞中,AP-1转录因子与CtBP一起抑制促进生长的基因.
由于AP-1/CtBP介导的抑制失败,Yorkie/Scalloped可以驱动瘤生长.

结论:

AP-1/CtBP与约克犬/贝行动并行,抑制共享的一组生长基因.
这种协调抑制对于消除缺陷细胞和防止瘤开始至关重要.
这些发现揭示了一种维持上皮质完整性和瘤抑制的新机制.

关键词:

AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 AP-1 在CtBP中使用.河马的信号传递在TNF/JNK信号传递方面.约克鱼/贝贝鱼在线观看表面上皮质的完整性这种新生病 neoplasia.器官的生长器官的生长器官的生长转录转录是一种转录.瘤抑制瘤抑制

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