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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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多模型方法的预测性能,用于在重症患者中以模型为基础的精确剂量定量皮佩拉西林

Lea Marie Schatz1, Sebastian Greppmair1, Alexandra K Kunzelmann1

  • 1Department of Anaesthesiology, LMU University Hospital, LMU Munich, Munich, Germany.

International journal of antimicrobial agents
|August 15, 2024
PubMed
概括

模型平均算法 (MAA) 改善了对piperacillin/tazobactam的模型信息精确剂量 (MIPD),提高了对抗生素暴露的优化. 在24小时内整合第二个TDM样本可以最大限度地实现目标,特别是在重症患者中.

关键词:
病情危急,病情危急.在重症监护病房的重症监护病房.基于模型的精确剂量定量.人口的药理动力学.败血症 这是一种败血症.治疗药物监测 治疗药物监测

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