肠道甲素过度生长患者的症状概况:系统性审查和元分析
Sepideh Mehravar1, Will Takakura2, Jiajing Wang1
1Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, Los Angeles, California.
概括
肠道甲素过度生长 (IMO) 与更严重的便秘和更少的腹有关. 了解这种独特的肠道微生物特征是患者护理的关键.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类健康 人类健康 人类健康
背景情况:
- 古代生物,一个独特的生命领域,包括涉及疾病的甲基生物.
- 肠道甲素过度生长 (IMO) 与便秘等疾病有关.
- 与IMO相关的特定症状需要进一步阐明.
研究的目的:
- 系统地审查和分析IMO患者的胃肠道症状的流行和严重程度.
- 为了比较IMO患者和没有IMO患者的症状表现.
主要方法:
- 对OVID MEDLINE和Cochrane数据库进行了系统的搜索.
- 计算了流行率,赔率比率 (OR),标准化平均差异 (SMD) 和置信区间 (CI).
- 分析了19项涉及1293名IMO患者和3028名对照者的研究.
主要成果:
- 患有IMO的患者报告了更高的胀气率 (78%),便秘 (51%),腹痛 (65%) 和气 (56%).
- 与对照组相比,IMO与便秘的患病率和严重程度显著增加有关.
- 相反,IMO显示腹和恶心的发病率和严重程度较低.
结论:
- 患有IMO的患者表现出明显的胃肠道症状特征,特别是便秘增加和腹减少.
- 这种独特的IMO现象型应纳入患者报告的结果措施.
- 建议进行进一步的研究,将IMO与微生物组机制相关联.
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