怀孕期间血压升高和长期心脏代谢健康结果
Christine Field1, William A Grobman, Jiqiang Wu
1Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio; and the Department of Preventive Medicine and the Department of Medicine, Northwestern University, Chicago, Illinois.
Obstetrics and gynecology
|August 15, 2024
概括
怀孕期间血压升高与多年后2型糖尿病和脂质失调的风险增加有关. 这项研究强调了血压监测对妇女长期心脏代谢健康的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 怀孕引起的高血压是造成母亲和胎儿不良后果的重要危险因素.
- 妊娠高血压疾病后的长期心脏代谢健康影响需要进一步调查.
研究的目的:
- 调查妊娠第三个月初高血压与产后10-14年的心脏代谢健康结果之间的关联.
- 评估与产前血压类别相关的2型糖尿病和脂质失调的风险.
主要方法:
- 预期高血糖和不良妊娠结果随访研究 (HAPO FUS) 的二次分析.
- 使用美国心脏病学会/美国心脏协会门的第三个月初血压的分类.
- 评估心脏代谢结果,包括2型糖尿病,LDL胆固醇,总胆固醇,HDL胆固醇和产后10-14年的甘油三.
- 对包括BMI,家族病史和葡萄糖水平在内的多种共变量进行了调整分析.
主要成果:
- 在4692名参与者中,高血压 (BP) 或高血压在8.5% (高血压),14.9% (第一阶段高血压) 和6.4% (第二阶段高血压) 观察到.
- 在11.6年的随访中,患有高血压或高血压的个体呈现出2型糖尿病 (调整后的相对风险[aRR]1.88-2.83) 和失脂症 (增加的LDL胆固醇aRR1.22-1.38,增加的总胆固醇aRR1.16-1.41,增加的甘油三酸aRR2.15-3.24) 的频率逐渐增加.
- 没有发现与低高密度脂蛋白 (HDL) 胆固醇有显著关联.
结论:
- 不良的心脏代谢结果,包括2型糖尿病和脂质失调症,在怀孕第三个月初的血压高于120/80毫米的个体中逐渐更频繁.
- 怀孕期间血压升高是长期心脏代谢功能障碍的重要预测因素.
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