召回的正气道压力装置与发生的癌症之间的关联:基于人口的研究
Tetyana Kendzerska1,2,3,4, Sachin R Pendharkar5,6,7, Robert Talarico8,2
1The Ottawa Hospital Research Institute, Ottawa, ON, Canada tkendzerska@toh.ca.
The European respiratory journal
|August 15, 2024
概括
在加拿大的一项大型研究中,飞利浦Respironics正气道压力 (PAP) 设备与癌症风险增加无关. 这项研究提供了关于这些广泛使用的PAP设备安全性的真实证据.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 飞利浦呼吸系统公司对2009年至2021年间分发的某些正气道压力 (PAP) 设备进行了召回.
- 与这些召回的PAP设备相关的现实世界健康影响,特别是癌症风险,仍然在很大程度上是未知的.
研究的目的:
- 调查被召回的Philips Respironics PAP设备与发生癌症的风险之间的关联.
- 在重大召回后,为PAP设备的安全提供现实世界的证据.
主要方法:
- 一项基于人口的回顾性研究使用加拿大安大略省的卫生行政数据进行.
- 在2012年至2018年期间开始治疗的新成年PAP使用者被确定并跟踪到2022年3月.
- 使用治疗权重的逆概率来平衡被召回和未被召回设备的用户之间的基线特征,并比较发生癌症的权重风险.
主要成果:
- 该研究包括231,692名成人PAP用户,其中25.1%使用被召回的设备.
- 在平均6.3年的随访期间,11,166人 (4.8%) 患上了癌症.
- 在倾向分数加权后,在被召回和未被召回设备的用户之间没有观察到发生癌症风险的统计学上显著差异 (危险比:0.97,95% CI:0.89-1.06).
结论:
- 在现实世界的人群中,召回的Philips Respironics PAP设备并没有独立地与患癌症的风险增加有关.
- 这些发现表明,经过对混因素进行调整后,这些特定的PAP设备的召回似乎不会增加癌症风险.
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