加强神经突出编码的缺点:皮质醇与危险饮酒之间的联系
Bailey B Harris1, Rajita Sinha2, Elizabeth V Goldfarb3,4,5,6
1Department of Psychology, UCLA, Los Angeles, California 90095.
概括
皮质醇增强了与酒精有关的事件的记忆,增加了饮酒的动机,特别是在风险饮酒者中. 这凸显了增强的突出编码如何导致不适应性行为.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 内分泌学 在内分泌学.
背景情况:
- 情感上突出的经历被更强烈地记住,受到皮质醇等激素的影响.
- 这种增强的记忆编码可以影响未来的行为,但与放大突出关系的联系尚不清楚.
- 风险饮酒与突出反应,记忆力和皮质醇水平的提高有关.
研究的目的:
- 调查放大突出编码,皮质醇,记忆偏差和随后的酒精动机之间的联系.
- 探索皮质醇如何影响记忆和大脑对社交饮酒者酒精暗示的反应.
- 为了确定敏感的突出反应是否预测记忆偏差和酒精动机.
主要方法:
- 采用双盲,交叉的药理设计.
- 综合功能磁共振成像 (fMRI),认知和动机测试.
- 研究了健康的男性和女性社会饮酒者在一系列的酒精消费水平.
主要成果:
- 皮质醇增强了与酒精有关的突出事件的记忆,创造了记忆偏差.
- 这种记忆偏差与增加饮酒动机有关.
- 冒险饮酒者对酒精对大脑突出反应的皮质醇效应增强,预测记忆偏差和动机.
结论:
- 皮质醇对突出酒精线索的记忆增强有助于增加酒精的动机.
- 敏感的突出反应,特别是风险饮酒者,调解皮质醇,记忆和寻求酒精行为的联系.
- 这些发现揭示了酒精使用背景下增强突出编码的不适应后果.
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