在固体器官移植的现代时代,细胞巨乳病毒视网膜炎
Sias J Scherger1, Kyle C Molina2, Alan G Palestine3
1Department of Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA; Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Transplantation proceedings
|August 15, 2024
概括
细胞巨乳病毒视网膜炎 (CMVR) 发生在13.2%的固体器官移植接受者 (SOTR) 中,有CMV病毒性. 常规眼科检查推用于SOTR与CMV病毒病,因为眼部症状往往不存在.
科学领域:
- 眼科医生 眼科 眼科
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 细胞巨乳病毒视网膜炎 (CMVR) 是已知的免疫功能低下个体的并发症.
- 与获得性免疫缺陷综合征 (艾滋病) 患者相比,有CMV病毒病的固体器官移植接受者 (SOTR) 中CMVR发病率和风险因素的数据有限.
研究的目的:
- 为了确定CMVR的发病率和识别风险因素,在经历CMV病毒病的SOTR中发现CMVR.
主要方法:
- 一项回顾性队列研究对在2018年1月1日至2022年3月16日期间接受眼科检查的CMV病毒性SOTR进行了回顾性队列研究.
- 使用单变量统计数据来分析与CMVR发展相关的风险因素.
主要成果:
- 该研究包括38名SOTR,主要是脏,心脏和肝脏接受者.
- 五名患者 (13.2%) 患有CMVR,在病毒病发作后平均69天被诊断出来.
- CMVR与先前的异构移植排斥和移植器官的类型有关;只有一个患者报告了症状.
结论:
- 尽管CMV疾病经常影响其他器官,但CMVR在CMV病毒性高风险SOTR中发生的频率显著.
- 大多数被诊断的患者没有眼部症状,这强调了常规眼科查SOTR与CMV病毒性病的重要性.
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