评估用于PSMA-PET/CT解释的同时对比增强诊断CT的附加值
Kelly Trinh1, David Z Chow2, Hyesun Park3
1Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114.
与PSMA-PET/CT同时进行对比增强诊断CT (DxCT) 并没有显著提高大多数前列腺癌征兆的诊断确定性. 然而,DxCT可能在初始阶段提供好处,提高诊断准确度.
科学领域:
- 核医学是一种核医学.
- 放射学 放射学是指放射学
- 在瘤学瘤学.
背景情况:
- 前列腺特异性膜抗原正子发射断层扫描/计算机断层扫描 (PSMA-PET/CT) 是前列腺癌的关键成像方式.
- 与PSMA-PET/CT同时使用对比增强诊断CT (DxCT) 的附加值仍在调查中.
研究的目的:
- 在前列腺癌患者中,评估与单独使用PSMA-PET/CT相比,并发DxCT是否能提高诊断确定性.
- 确定DxCT可能提高诊断性能的特定临床场景.
主要方法:
- 一项回顾性多读者研究分析了前列腺癌患者与DxCT并发或不并发的PSMA-PET/CT扫描.
- 六个核放射学阅读器评估了PSMA-avid病变的诊断确定性,有或没有DxCT,以随机的,盲目的方式.
- 在两种成像方案之间比较了评价者间一致性和整体诊断确定性.
主要成果:
- 对PSMA-PET/CT和联合DxCT-PET/CT均观察到良好的评价者间一致性.
- 总体诊断确定性在PSMA-PET/CT (92%) 和DxCT-PET/CT (92%) 之间是相似的,在大多数指示中添加DxCT没有显著的优势.
- 一个轻微的,无意义的趋势 (p=0.08) 支持DxCT-PET/CT组合用于前列腺癌的初始阶段.
结论:
- 单独PSMA-PET/CT就为前列腺癌成像提供了良好的读者间一致性.
- 同时进行DxCT并不能显著提高大多数迹象的诊断确定性,但可能对初始分期有益.
- 进一步的研究可能会澄清DxCT与PSMA-PET/CT结合的具体作用.
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