在膀癌中对TERT进行全面的行为评估
Meryem El Azzouzi1, Hajar El Ahanidi2, Ilias Hassan3
1Biology and Medical Research Unit, CNESTEN, Rabat, Morocco; Rabat Medical and Pharmacy School, Mohammed V University in Rabat, Rabat, Morocco.
Urologic oncology
|August 15, 2024
概括
端粒酶逆转录酶 (TERT) 促进剂的改变是膀癌的关键. 甲基化和突变影响癌症的进展,而TERT表达和端粒长度影响生存结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 端粒酶活性对于癌症的发展和进展至关重要.
- 端粒酶逆转录酶 (TERT) 促进体的改变,包括突变和表观遗传变化,对于膀癌的诱导和进展至关重要.
研究的目的:
- 为了研究端粒酶逆转录酶 (TERT) 促进剂在膀癌中的作用.
- 分析TERT促进体甲基化,TERT促进体突变,端粒长度和膀瘤中TERT表达之间的关系.
- 评估这些分子特征对患者生存的预后意义.
主要方法:
- 分析了100个膀瘤组织.
- 评估THOR甲基化状态.
- 检测TERT促进子突变的检测.
- 测量端粒长度和TERT表达的方法.
主要成果:
- 在88%的患者中观察到THOR区域的高甲基化,在60%的患者中观察到TERT促进器突变.
- 在所有膀癌阶段和等级中都发生了TERT促进物甲基化,而在晚期阶段发现了突变.
- 高TERT表达和长端粒与非侵入性膀癌有关,并预测了更长的无病和整体存活时间.
结论:
- TERT促进剂甲基化和突变与膀癌的发展有关.
- 这些分子变化提供了预后信息,并增强了对癌症中端粒生物学的理解.
关键词:
生物标志物生物标志物膀癌是一种癌症.基因表达 基因表达 基因表达突变突变是一种突变.TERT的发起人是 TERT 的发起人.托尔·托尔 (Thor Thor) 是一个非常有价值的人.端粒长度 端粒长度 端粒长度更多相关视频
相关概念视频
Urinary Bladder
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Assessment of the Rectum and Anus
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Infection IV: Nursing Management
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...


