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酸是PIEZO2通道和机械灵敏度的内源性负调节剂

Matthew Gabrielle1, Yevgen Yudin1, Yujue Wang2,3

  • 1Department of Pharmacology, Physiology & Neuroscience, Rutgers University New Jersey Medical School, Newark, NJ, USA.

Nature communications
|August 15, 2024
PubMed
概括

研究人员确定了脂质调节剂,酸和 lysophosphatidic 酸 (LPA),可以选择性地抑制机械敏感的 PIEZO2 通道. 脂酶D (PLD) 途径控制PIEZO2的活动,影响触摸和疼痛.

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