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Updated: Jun 16, 2025

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FIGNL1-FIRRM对于介质重组是必不可少的,并防止DNA损伤独立的RAD51和DMC1加载

Akbar Zainu1, Pauline Dupaigne2, Soumya Bouchouika1,3

  • 1Institut de Génétique Humaine, University of Montpellier, CNRS, Montpellier, France.

Nature communications
|August 15, 2024
PubMed
概括

菲吉丁类1 (FIGNL1) 和其调节剂FIRRM对于雄性小鼠中完整的半变异是必不可少的. 这种复合物限制了DNA修复蛋白的积累,确保了适当的同源重组和半变化期间的链入侵.

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