相关实验视频

Updated: Jun 27, 2026

Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain
09:25

Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain

Published on: May 21, 2019

6.7K

在小鼠大脑中全面识别与ubiquitin-like 3 (UBL3) 相互作用的蛋白质

Hiroshi Ageta1, Tomoki Nishioka2,3, Hisateru Yamaguchi4

  • 1Division for Therapies Against Intractable Diseases, Center for Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan. hiage@fujita-hu.ac.jp.

Molecular brain
|August 15, 2024
PubMed
概括

乌比奎丁类3 (UBL3) 影响小细胞外囊泡 (sEV) 和RNA代谢. 这项研究确定了新的UBL3相互作用蛋白,推进了神经退行性疾病研究.

关键词:
神经退行性疾病的神经退行性疾病后翻译修改后的修改.蛋白质组学是指蛋白质组学.在RNA结合蛋白质中的RNA结合蛋白.小细胞外囊泡 (小细胞外囊泡) (sEVs)类似于乌比奎丁的3 (UBL3)

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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology10:25

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
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Regulated Protein Degradation

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Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...