在5岁以下的发育不良儿童中,巴卡尔DNA的全球甲基化和认知表现
Ahmad Rusdan Handoyo Utomo1, Yusnita Yusnita2, Siti Maulidya Sari2
1Graduate School of Biomedical Science, Universitas YARSI, Jakarta, Indonesia.
Journal of biomedical research
|August 16, 2024
概括
全球DNA甲基化,以5-甲基 (5mC) 水平来表示,在不发育的印尼儿童中较低. 在口腔抽样中较低的5mC可能表明衰老风险,但与认知表现无关.
科学领域:
- 表观遗传学和儿童健康
- 营养流行病学 营养流行病学
- 发展生物学 发展生物学
背景情况:
- 发育迟缓影响了20%的印度尼西亚五岁以下的儿童,慢性母亲营养不良是关键的危险因素.
- 孕产妇营养不良会通过表观遗传机制影响儿童的发育,例如全球DNA甲基化.
- 5-甲基-细胞氨酸 (5mC) 作为全球DNA甲基化标志物.
研究的目的:
- 为了评估印尼儿童口腔扫描中的5-甲基-细胞素 (5mC) 水平.
- 调查5mC水平与衰老风险之间的关联.
- 探索5mC水平与认知表现之间的关系.
主要方法:
- 一项涉及印度尼西亚0-5岁231名儿童的横截面研究.
- 使用酶相关免疫吸收试验测量口腔抹纸DNA中的5mC水平.
- 使用韦克斯勒学前和初级智力尺度评估认知功能.
主要成果:
- 发育迟缓的发病率在0-2岁儿童中为37%,在2岁以上儿童中为30%.
- 在严重缩的儿童和幼儿中观察到明显较低的5mC水平.
- 在5mC水平和认知得分之间没有发现统计学意义上的关联.
结论:
- 全球较低的DNA甲基化,如口腔抽样中5mC水平的降低,与印尼儿童的发育迟缓有关.
- 虽然5mC可以作为衰老风险的潜在生物标志物,但它似乎与这个队列的认知表现无关.
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