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通过下一代测序来识别新型HLA-DRB3*03:69等位基因

Isabella Fantini Molinari1, Anthony Marçal Leão de Oliveira1, Fernanda Pelisson Massi1,2

  • 1Department of Clinical Analysis and Biomedicine (DAB), Postgraduate Program in Biosciences and Physiopathology (PBF), Laboratory of Immunogenetics at the State University of Maringá (LIG-UEM), Maringá, Paraná, Brazil.

HLA
|August 16, 2024
PubMed
概括

一个新的人类白细胞抗原 (HLA) 基因,HLA-DRB3*03:69,已经被确定. 这种新等位基因与先前已知的等位基因区别在于,在3号外基因中单个核酸的变化.

关键词:
巴西 巴西 巴西 巴西.骨髓移植 骨髓移植高分辨率的高分辨率解决方案一个新的等位基因.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...