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Updated: Jun 16, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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在RASmut疾病模型中通过药理CDK4/6和MEK抑制引起的可分离细胞周期停止和免疫反应

Jin Wu1, Jianxin Wang1, Thomas N O'Connor1

  • 1Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Molecular cancer therapeutics
|August 16, 2024
PubMed
概括

结合CDK4/6和MEK抑制剂,如palbociclib和trametinib,通过阻止细胞生长和激活免疫通路,对软组织肉瘤有很大的希望. 这一策略为RAS突变癌症提供了新的治疗途径.

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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