阿尔多和因与人体构成的性别相关联:基于人口的队列研究
Gregory L Hundemer1,2, Mohsen Agharazii3, François Madore4
1Department of Medicine, Division of Nephrology, University of Ottawa, Ottawa, ON K1H 7W9, Canada.
The Journal of clinical endocrinology and metabolism
|August 16, 2024
概括
雷宁- ангиотензин- алдостерон系统 (RAAS) 的活性对男性和女性的身体组成产生不同的影响. 较高的RAAS活性与不良的身体组成有关,不管体重如何,观察到的性别特异性模式.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 人体生理学 人体生理学
背景情况:
- 氨酸- ангиотензин- алдостерон系统 (RAAS) 与肥胖有关.
- 在非肥胖个体中,RAAS活动和身体组成之间的关联并未被性别定义得很好.
研究的目的:
- 检查阿尔多斯和宁水平之间的性别特异关系以及各种身体组成指标.
- 在一般成年人群中调查这些关联.
主要方法:
- 一项基于人口的队列研究在加拿大北克进行.
- 分析了3687名年龄在40-69岁之间的成年人.
- 使用人类计量,生物电阻和心脏核磁共振,以及血中阿尔多斯和雷宁的测量,评估了身体组成.
主要成果:
- 在男性中,较高的阿尔多素和氨酸与腰围增加,腰与部比,脂肪质量以及瘦肉/肌肉质量减少相关.
- 阿尔多,但不是雷宁,与男性心脏脂肪增加有关.
- 在女性中,较高的雷宁与腰围增加,腰比和心脏脂肪增加相关,而雷宁和阿尔多素都与脂肪质量增加有关.
结论:
- 增加RAAS活性与不良的身体组成有关,无论体重如何.
- 在RAAS活动与人体构成之间的特定关联中,性别差异显著.
相关概念视频
01:33Hormonal Regulation
33.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.0K
01:31Hormones of the Adrenal Glands
2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
01:25Antihypertensive Drugs: Direct Renin Inhibitors
513
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
513
01:17Hormonal Regulation of Blood Pressure
2.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.5K
01:26Adrenergic Receptors: β Subtype
1.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.6K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
405
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
405