在人类中,有12小时超速基因程序的证据
Bokai Zhu1,2,3, Silvia Liu2,4, Natalie L David1,5,6
1Aging Institute of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Npj biological timing and sleep
|August 16, 2024
概括
研究人员在人类白细胞中发现了12小时的超射节律,反映了海洋生物的基因模式. 这一发现提供了人类这种生物节奏的第一个直接证据.
科学领域:
- 时间生物学 时间生物学
- 人体生理学 人体生理学
- 分子生物学分子生物学
背景情况:
- 许多生物,包括小鼠和海洋物种,都表现出12小时的超射频节奏.
- 以前缺乏关于人类12小时超日节律的直接证据.
研究的目的:
- 为了研究在人体外围白细胞中存在12小时的超日节律.
- 为了比较人类的转录节奏与海洋生物中发现的转录节奏.
主要方法:
- 对外围白细胞进行了前性时转录组分析.
- 随着时间的推移,从三个健康的人类参与者收集了样本.
主要成果:
- 三位参与者都独立地显示出强大的~12小时的转录节奏.
- 这些节奏在与RNA和蛋白质代谢相关的分子程序中观察到.
- 鉴定到的人类基因程序显示强烈的同质性,以circatidal基因程序在Cnidarian海洋物种.
结论:
- 这项研究提供了人类12小时超视频节律的第一个直接证据.
- 人类RNA和蛋白质代谢中的12小时节律与海洋环状基因程序有相似之处.
- 这些发现表明,在不同物种之间存在潜在的生物保护机制.
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