Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

8.1K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.1K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.2K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.2K
Non-gated Ion Channels01:24

Non-gated Ion Channels

6.7K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
6.7K
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

1.5K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
1.5K
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action01:17

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

1.7K
Nondepolarizing neuromuscular blockers induce paralysis by competitively blocking nicotinic acetylcholine receptors at the muscle end plate. Examples include pancuronium, mivacurium, vecuronium, and rocuronium. These quaternary ammonium derivatives are administered intravenously, are poorly absorbed, and are excreted via the kidneys.
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...
1.7K
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

3.0K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
3.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Testing Practices and Applications of Flywheel Resistance Technologies-Implications for Performance Assessment and Injuries From a Survey Study.

Journal of strength and conditioning research·2026
Same author

Neuromuscular and Subjective Recovery Responses to Day and Night Fixtures During Congested and Noncongested Microcycles in Professional Soccer Players.

Journal of strength and conditioning research·2026
Same author

Influence of contextualized physical performance metrics on offensive and defensive outcomes in professional football players.

Biology of sport·2026
Same author

Within-System Agreement Between Real-Time and Post-Processed Data Using Dynamix from League Optical Tracking (Hawk-Eye) in Professional Football.

Sports (Basel, Switzerland)·2026
Same author

Comparison of External Load Demands Across Three Competitive Tiers in Spanish Football: A Three-Season Single-Club Study.

Journal of strength and conditioning research·2026
Same author

Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice.

iScience·2026

相关实验视频

Updated: Jun 16, 2025

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

21.4K

在脊柱运动神经元中,Kv2通道不作为规范延迟整流器起作用.

Calvin C Smith1, Filipe Nascimento1, M Görkem Özyurt1

  • 1Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

iScience
|August 16, 2024
PubMed
概括

成熟的运动神经元中的Kv2.1通道淘汰并没有影响肌肉力量或刺激能力. Kv2.2 频道可以补偿 Kv2.1 的频道.

关键词:
行为神经科学 行为神经科学神经科学是一个神经科学.感官神经科学是一种神经科学.

更多相关视频

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

9.5K
Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

9.1K

相关实验视频

Last Updated: Jun 16, 2025

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

21.4K
The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

9.5K
Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

9.1K

科学领域:

  • 神经科学是一个神经科学.
  • 运动神经元生理学运动神经元生理学
  • 离子通道功能的功能

背景情况:

  • 胆固醇C-纽扣突触扩大运动神经元输出,增加肌肉力量.
  • 之前认为,在新生儿运动神经元中,后突触聚合的Kv2.1通道对于这种放大至关重要.

研究的目的:

  • 研究Kv2.1通道在成熟的运动神经元刺激性和功能中的作用.
  • 为了确定Kv2.1通道功能是否对于成年小鼠的C-button放大至关重要.

主要方法:

  • 在成熟的小鼠运动神经元中,Kv2.1通道的有条件淘汰.
  • 在体外进行电生理学记录,以评估运动神经元刺激性和对肌肉素的反应.
  • 在体内评估电肌图活动和高强力任务的性能.
  • 免疫组织化学分析检查Kv2.1和Kv2.2通道表达.

主要成果:

  • Kv2.1通道淘汰对成熟的运动神经元刺激性或对肌肉素的反应的影响很小.
  • 药理上对Kv2通道的阻塞在试验室中对成熟的运动神经元激发的影响很小.
  • 在体内,Kv2.1淘汰赛并没有改变电肌图放大或高强力任务的性能.
  • Kv2.2通道表达在脊柱运动神经元中,并与Kv2.1在C-buttons.

结论:

  • Kv2.1通道功能对于C-button放大或成熟的运动神经元刺激性来说并不必不可少.
  • Kv2蛋白可能在运动神经元中发挥非导电作用.
  • 在这个非导体的角色中,Kv2.2可以替代Kv2.1的功能.