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Updated: Jun 16, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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多尺度模拟揭示了p53C相位分离的驱动力,由致癌突变加速

Yawei Yu1, Qian Liu1, Jiyuan Zeng1

  • 1Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University Shanghai 200438 People's Republic of China ghwei@fudan.edu.cn.

Chemical science
|August 16, 2024
PubMed
概括

在p53中与癌症相关的突变加快了其液体-液体相分离 (LLPS) 和聚合. 分子模拟揭示了这些突变如何破坏p53结构,促进凝结物形成并提供新的治疗点.

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