在城市家庭中,人类,动物和环境之间共享细菌菌株
Daehyun D Kim1, Jenna M Swarthout2, Colin J Worby3
1Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA.
medRxiv : the preprint server for health sciences
|August 16, 2024
概括
城市住宅中的环境细菌携带抗生素耐药性基因. 污染的饮用水会在人与人之间传播这些耐药细菌,这凸显了需要进行水处理来制传播的必要性.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 城市生态学 城市生态学
背景情况:
- 识别细菌传播是控制致病性和抗生素耐药细菌的关键.
- 低收入和中等收入国家的快速城市化加剧了这一挑战.
- 了解家庭环境的作用对于有效的干预至关重要.
研究的目的:
- 评估细菌菌株共享和抗生素耐药性基因 (ARG) 的传播.
- 调查肯尼亚内罗毕城市非正式定居点内的传播途径.
- 确定饮用水在细菌传播中的作用.
主要方法:
- 从50个家庭收集了321个样本 (人类,家禽,狗,土壤,水).
- 使用聚合隔离殖民地-seq (PIC-seq) 来分析大肠杆菌菌株和ARG.
- 检查了菌株多样性,共享模式和ARG跨样本类型的重叠.
主要成果:
- 环境细菌含有临床相关的ARG,证实了环境在耐药性传播中的作用.
- 在家庭中,菌株共享和抗体相似性之间的强烈相关性表明了克隆传播.
- 人与动物之间分享大肠杆菌是罕见的,但在人与饮用水之间是常见的.
结论:
- 污染的饮用水大大促进了人与人之间的大肠杆菌菌株共享.
- 家庭环境充当了抗生素耐药细菌的储存库.
- 水处理干预措施可以有效地破坏家庭环境中的细菌传播途径.
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