性,年龄,APOE和常见的健康风险因素对人类大脑功能的相互作用影响
Tengfei Li1,2, Jie Chen3, Bingxin Zhao4
1Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
medRxiv : the preprint server for health sciences
|August 16, 2024
概括
大脑衰老涉及诸如性和健康风险等复杂因素. 这项研究发现,这些因素如何影响大脑连接,在性别上存在显著差异,这突显了理解大脑衰老的综合方法的必要性.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 公共卫生 公共卫生
背景情况:
- 大脑衰老受性别,年龄,遗传和生活方式因素的影响.
- 了解这些因素对大脑功能连接的综合影响至关重要,但不太了解.
研究的目的:
- 调查性别,年龄,阿波利波蛋白E (APOE) 基因型和十个可修改的健康风险因素与大脑功能连接的联合关联.
- 探索这些因素对大脑衰老的相互作用影响.
主要方法:
- 利用了36630名英国生物库参与者 (年龄在44-81岁) 的数据.
- 通过静止状态功能磁共振成像 (rs-fMRI) 评估性别,年龄,APOE基因型,10个健康风险因素和大脑功能连接.
- 分析了网络内部和网络间的功能连接和连接强度.
主要成果:
- 高血压,BMI和教育是影响大脑连接的关键因素.
- 观察到与APOE4,酒精消费,糖尿病,BMI和教育有显著的性别特异性相互作用.
- 性和过度饮酒/APOE4之间的负面相互作用影响了特定的大脑网络,而中度饮酒显示有保护作用. 还注意到与BMI和高血压有关的与年龄相关的相互作用.
结论:
- 性差异显著调节年龄,APOE4和健康风险对大脑功能连接的影响.
- 考虑这些综合因素的综合方法对于理解大脑衰老机制至关重要.
- 研究结果强调,在脑健康干预中需要个性化策略.
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