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使用光谱技术对4,4'-米诺-2,2'-乙烯二硫酸与金属离子进行药理学评估和结合行为

Madeeha Shabnam¹, Eman A Alabdullkarem², Muhammad Saeed Jan³

¹Department of Chemistry, Women University, Mardan, KP, Pakistan.

|August 16, 2024

概括

4,4'-米诺-2,2'-stilbenedisulfonic 酸 (DSD) 能够有效地检测重金属离子,并显示出强大的抗癌和抗微生物活性. 这种多功能化合物作为传感器和用于治疗癌症和阿尔茨海默病等疾病的多方面的药物开发具有前景.

科学领域:

环境科学环境科学
生物化学生化学
药用化学医学化学

背景情况:

重金属离子 (HMI) 污染带来了重大的环境和毒理风险.
4,4 - - 米诺-2,2 - - 二硫酸 (DSD) 是一种已知的化合物,在重金属检测和癌症治疗中具有潜在的应用.
需要对HMI和各种疾病的新疗法产生有效的传感器.

研究的目的:

开发DSD作为环境样本中重金属离子的选择性传感器.
研究DSD在光成像中的潜力,用于癌细胞治疗.
为了评估DSD的酶抑制活动,以潜在的治疗应用.

主要方法:

光和紫外线可见光谱学被用来评估DSD对各种重金属离子的选择性.
进行了体外酶抑制试验,以评估DSD对乙胆酶 (AChE),丁胆酶 (BChE),环氧酶 (COX) 和脂氧酶 (LOX) 的活性.
使用DPPH和ABTS试验评估抗氧化活性,使用MTT试验测定癌细胞系的抗癌作用. 对特定的病原体进行了抗菌活性测试.

主要成果:

DSD通过光诱导电子转移 (PET) 途径的抑制来证明对Sn2+离子的选择性传感.
DSD 显著抑制了 AChE 和 BChE,表现优于标准药物加兰大胺.
与cefixime相比,DSD对NIH/3T3,HeLa和MCF-7细胞系表现出强烈的抗癌活性,并表现出与Candida albicans和Pseudomonas aeruginosa相比的优越抗菌活性.

结论:

DSD是环境监测中选择性检测Sn2+离子的有希望的候选者.
DSD具有多方面的药理性质,包括显著的酶抑制,抗氧化,抗癌和抗菌作用.
这些发现支持DSD作为一种多功能化合物的潜力,既用于环境传感,也用于开发新型治疗剂,特别是用于癌症治疗.

关键词:

在ABTS中,ABTS是ABTS.这就是阿切.BChE BChE 在线阅读科克斯 (COX) 是一个在 DPPH 的情况下,DPPH 是 DPPH.这里是LOX LOX.在MTT测试中使用MTT测试.

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