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免疫治疗在RET融合阳性NSCLC中的有效性:一个元分析

Zhongsheng Peng¹, Kaibo Ding¹, Mingying Xie²

¹Department of Medical Thoracic Oncology, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

|August 16, 2024

概括

免疫疗法在非小细胞肺癌 (NSCLC) 中具有有限的有效性,在转移过程中重新排列 (RET) 融合. 与化疗联合治疗为这些患者提供了更好的结果.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
免疫治疗是一种免疫疗法.

背景情况:

在转移 (RET) 过程中重新排列的基因融合是非小细胞肺癌 (NSCLC) 的罕见驱动突变,在1-2%的病例中发现.
虽然免疫疗法在具有野生型基因的高级NSCLC中有效,但其在RET融合阳性NSCLC中的有效性仍在研究中.

研究的目的:

系统地评估免疫治疗在RET融合阳性NSCLC患者中的有效性.
为了比较单剂免疫疗法与组合疗法 (免疫疗法加化疗) 的疗效.

主要方法:

进行了对现实世界证据 (RWE) 研究的元分析.
在PubMed和Web of Science数据库中搜索相关研究.
分析的结果包括客观应答率 (ORR),疾病控制率 (DCR),无进展生存率 (PFS) 和整体生存率 (OS).

主要成果:

包括10项RWE研究,涉及7145名患者.
整体客观反应率 (ORR) 为24.0%,疾病控制率 (DCR) 为61.0%.
聚合的中位数无进展生存 (PFS) 为4.17个月,中位数整体生存 (OS) 为17.22个月.
与单剂免疫疗法相比,免疫疗法加化疗显示出更高的ORR (43%对17%),DCR (74%对45%) 和PFS中位数 (6.69对2.96个月).

结论:

RET融合与NSCLC患者免疫治疗反应不佳有关.
免疫疗法加化疗的联合治疗似乎为RET融合阳性NSCLC提供了比单疗更大的临床益处.

关键词:

免疫治疗是一种免疫疗法.进行元分析分析.非小细胞肺癌是非小细胞肺癌.在RET的融合中,RET的融合.

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