在患有埃索诺菲尔性食道炎和持续的缓解后失足症的儿童中进行的测量结果
Dotan Yogev1,2, Lev Dorfman3,4, Sherief Mansi3,4
1Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical Center Jerusalem Israel.
JPGN reports
|August 16, 2024
概括
异敏性食道炎 (EoE) 缓解后的持续性消化不良是罕见的. 高分辨率阻抗计量 (HRIM) 在这些儿科患者中揭示了食道低运动性和异常的玻尿酸清除.
科学领域:
- 胃肠病学 胃肠病学
- 儿科胃肠病学 儿科胃肠病学
- 食道运动障碍 食道运动障碍
背景情况:
- 性食道炎 (EoE) 是食道的过敏性炎症状况.
- 缺食症是活跃EoE的常见症状,但即使在组织学缓解后也可能持续存在.
- 在患有EoE的儿童和缓解后持久性消化不良症的儿童中,人体测量结果没有得到很好的描述.
研究的目的:
- 描述高分辨率阻抗测量 (HRIM) 在患有EoE的儿科患者中发现的结果,尽管实现了组织学缓解,但患有持续性消化障碍.
- 调查EoE患者持续性消化不良的潜在原因,这些患者没有表现出纤维静脉变化的迹象.
主要方法:
- 在2013年至2023年间在三级医疗中心对儿科EOE患者的回顾性图表审查.
- 纳入标准:EoE诊断,持久性消化不良和组织学缓解 (<15种乙素/高功率场).
- 收集的数据包括诊断,内镜,活检,治疗和HRIM发现.
主要成果:
- 只有四名患者符合本病例系列的严格纳入标准,这表明罕见发生 (<0.05%的流行率).
- 所有四名患者都表现出低动性食道和HRIM上的异常玻尿酸清除.
- 具体的诊断包括无效的食道运动性 (2名患者),aperistalsis (1名患者) 和achalasia类型1 (1名患者).
结论:
- 经过EoE缓解后的持续性消化不良并不常见.
- 消化道不运动,特别是低运动模式,可能是这些儿童持续性消化障碍的基础.
- 考虑EoE患者的HRIM,尽管经历了组织学愈合,但患有持续性消化不良的患者.
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