在精神疾病中白质形态学的多尺度异质性
Ashlea Segal1,2,3, Robert E Smith4,5, Sidhant Chopra6
1Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
bioRxiv : the preprint server for biology
|August 16, 2024
概括
精神疾病中的白质体积偏差高度个性化,与群体平均值不同. 虽然比灰质变化少见,但在自闭症和精神分裂症的大脑网络中出现了一些模式.
科学领域:
- 神经成像是一种神经成像.
- 大脑形态学 大脑形态学
- 心理健康研究 心理健康研究
背景情况:
- 经典研究忽视了精神疾病神经生物学中的个体差异.
- 规范模型显示,群体手段并不代表灰色物质中的个体.
- 在患有精神疾病的个体中,白质形态学的变异性尚未得到充分理解.
研究的目的:
- 使用规范建模绘制白质体积偏差的个体间变异性的地图.
- 描述这些偏差在多个空间尺度上的异质性.
- 为了调查白质偏差是否聚集在特定的大脑路径或网络在各种精神障碍.
主要方法:
- 应用曲率贝叶斯线性回归规范模型到T1加权MRI数据.
- 分析了1294名患有6种精神障碍的个人和1465名对照者的白质体积偏差.
- 开发了一个框架来评估从voxels到大规模大脑网络的偏差异性.
主要成果:
- 白质体积偏差在参与者之间高度异质,很少有持续影响的声音.
- 负偏差 (体积减少) 聚合在自闭症和精神分裂症的共同区域/区域 (高达35%).
- 白质偏差的总体患病率低于以前在灰质中看到的.
结论:
- 精神疾病中的白质体积偏差是高度个体特异和空间异质的.
- 在自闭症和精神分裂症中观察到偏差聚合到共同的途径中,但在其他疾病中没有.
- 结果突出了群体平均方法的局限性,以及在精神疾病研究中需要个体级别分析.
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