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Updated: Jun 16, 2025

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

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Published on: April 21, 2015

抗病毒Mx蛋白具有古老的起源,在真核生物中广泛分布

Caroline A Langley^1,2,3, Peter A Dietzen^1,2,3, Michael Emerman^2,3

¹Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA.

bioRxiv : the preprint server for biology

|August 16, 2024

概括

Mx蛋白质是Dynamin超级家族中的古老抗病毒药物,起源于脊椎动物干扰素系统之前. 这些蛋白质具有深厚的进化根源,早于Eukarya的起源,并显示病毒相互作用的历史.

科学领域:

进化生物学是进化的生物学.
病毒学病毒学
细胞动态细胞动态

背景情况:

Mx蛋白是被发现在哺乳动物中的强效广泛抗病毒药物.
它们属于Dynamin超级蛋白家族 (DSP),参与关键的细胞过程.
Mx蛋白的进化起源和古老功能在很大程度上是未知的.

研究的目的:

为了研究Mx蛋白质的进化起源.
为了确定Dynamin超级家族内的Mx蛋白的遗传关系.
了解DSP中病毒和抗病毒功能的古老历史.

主要方法:

具有越来越多的分类范围的族群基因组分析.
超级家族Dynamin的遗传学重建.
对宿主和病毒编码的DSP进行比较分析.

主要成果:

Mx蛋白早于脊椎动物的干扰素信号系统.
一个古老的单体DSP血统包括脊椎动物/无脊椎动物Mx,真菌MxF和植物/藻类Dynamin 4A/4C蛋白质.
类似Mx的蛋白质可以追溯到Eukarya的起源.
在DSP中出现反复的病毒基因盗窃的证据,宿主和NCLDV编码的DSP间隔在四个谱系中.

结论:

Mx蛋白具有古老的起源,可以追溯到Eukarya的黎明.
超级Dynamin家族在编码宿主抗病毒功能和受到病毒盗窃的同时有着悠久的历史.
了解DSP进化提供了对主体-病原体在深层进化时间的相互作用的见解.

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