前额叶皮层的子区域为主要视觉皮层提供了独特的视觉和行为反调制
S Ährlund-Richter1, Y Osako1, K R Jenks1
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
bioRxiv : the preprint server for biology
|August 16, 2024
概括
哺乳动物前额叶皮层 (PFC) 调节感官处理. 截然不同的PFC区域,前带状皮层 (ACA) 和轨道前皮层 (ORB),根据行为和兴奋,独特地塑造视觉皮层活动.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 皮层电路 皮层电路
背景情况:
- 哺乳动物前额叶皮层 (PFC) 通过远程轴突投射来调节感官处理.
- 独特的PFC子区域具有独特的连接性和功能角色,表明用于感官处理的模块化反机制.
- 了解PFC投影如何在不同行为状态中塑造感官皮层活动,对于完善皮层层次模型至关重要.
研究的目的:
- 研究从前皮层 (ACA) 和PFC的腹侧轨道前皮层 (ORB) 的投影如何调节初级视觉皮层 (VISp) 中的感觉处理.
- 划出ACA和ORB投影对不同行为状态的视觉处理的独特结构和功能贡献.
- 提供一个精细的皮层层次模型和PFC对感官信息处理的影响.
主要方法:
- 在小鼠中进行轴突追踪以映射投影模式.
- 轴突和体质2光子成像以记录神经活动.
- 化学遗传学操纵以评估通过PFC投影的功能调制.
主要成果:
- 在VISp中,ACA和ORB在皮层中呈现出不同的投影模式.
- 在VISp中的ACA投影比ORB投影更强烈地表示视觉刺激信息.
- ACA输入增强了VISp中的视觉编码,由唤醒调节;ORB输入调节了运动/唤醒相关活动,并减少了高对比度刺激编码.
结论:
- ACA和ORB反预测具有可分离的模式,并编码不同的信息,独特地为VISp活动做出贡献.
- 这些发现支持一种精细的皮层层次模型,其中特定的PFC投影塑造基于行为背景的感官处理.
- PFC投影的独特特性,而不是一般化的效应,是调节不同行为状态期间VISp活动的关键.
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