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Updated: Jun 16, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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工程合成激动剂用于有针对性的激活Notch信号

David H Perez1, Daniel Antfolk1, Xiomar E Bustos1

  • 1Department of Immunology, Moffitt Cancer Center, Tampa, FL 33602, USA.

bioRxiv : the preprint server for biology
|August 16, 2024
PubMed
概括

研究人员设计了合成的诺奇激进分子 (SNAG) 蛋白来通过机械力激活诺奇信号. 这些SNAG针对特定的生物标志物,为癌症和免疫调节提供新的治疗可能性.

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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