相关实验视频

Updated: Jun 16, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

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睡眠和白天的替代聚亚脱位与人类APA相关的大脑疾病有关

Carlos C Flores1, Nickolas A Pasetto1, Hongyang Wang1

  • 1Washington State University.

Research square
|August 16, 2024
PubMed
概括

睡眠和昼夜节律的干扰会影响各种疾病. 这项研究确定了与睡眠相关的老鼠大脑中独特的替代多化 (APA) 模式,为大脑疾病机制提供了新的见解.

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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay11:22

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

Published on: August 26, 2018

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Dissection of Hippocampal Dentate Gyrus from Adult Mouse07:42

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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