大脑不对称的纵向变化追踪生活方式和疾病
Karin Saltoun1,2, B T Thomas Yeo3,4,5,6,7,8, Lynn Paul9
1The Neuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, McGill University, Montreal, Canada.
Research square
|August 16, 2024
概括
人类大脑的不对称性,或半球专业化,在整个成年期发生变化,挑战以前的假设. 这些大脑变化与生活方式因素和主要疾病相关,突出显示神经可塑性.
科学领域:
- 神经科学是一个神经科学.
- 人类生物学 人类生物学
- 遗传学和表观遗传学
背景情况:
- 人类大脑表现出显著的半球专业化,特别是独特的认知能力.
- 大脑不对称性受到非遗传因素的影响,这表明环境或发育影响.
- 以前的理解假定大脑不对称性在成年时基本保持静态.
研究的目的:
- 为了研究大脑不对称的纵向变化在大型成人队列中.
- 探索大脑不对称性变化与各种表型和生活方式变量之间的联系.
- 为了确定大脑不对称性变化与主要疾病类别的相关性.
主要方法:
- 利用英国生物库,最大的纵向大脑成像成年人数据集.
- 分析的大脑不对称性随着时间的推移而变化,与11个类别的959个表型变量相关.
- 大脑不对称的相关变化与纵向的生活方式标记物和医学诊断.
主要成果:
- 在整个成年期中,大脑不对称性的持续变化得到证明,这表明神经可塑性.
- 在不对称性变化和广泛的表型变量之间发现了强有力的关联.
- 观察到大脑不对称性变化的同时发生与生活方式标志物的转变以及与疾病类别的相关性.
结论:
- 大脑不对称性在成年时不是固定的,而是动态变化,反映神经可塑性.
- 这些动态变化与个人的生活方式有关,并对健康和疾病产生影响.
- 挑战了长期以来关于成年人保存不对称的神经系统的假设.
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