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Evelien Kramer¹, Ketki Patil², Vassilis Triantis¹

¹FrieslandCampina, Amersfoort, Netherlands.

Frontiers in nutrition

|August 16, 2024

概括

用牛奶脂肪球体膜 (MFGM) 丰富的乳清对轮状病毒,RSV和SARS-CoV-2具有抗病毒活性. 这项研究确定了MFGM丰富乳清中的关键成分,有助于其对常见婴儿病毒感染的保护作用.

科学领域:

病毒学病毒学
生物化学生物化学
免疫学免疫学免疫学

背景情况:

罗塔病毒和RSV是常见的婴儿病毒感染,导致严重的胃肠炎和呼吸系统问题.
牛奶衍生因素,包括蛋白质,可以提供对粘膜病毒感染的保护.
最近的研究表明,牛奶蛋白也可能对抗SARS-CoV-2.

研究的目的:

评估牛乳脂肪球膜 (MFGM) 丰富乳清对轮状病毒,RSV和SARS-CoV-2的抗病毒活性.
鉴定MFGM丰富乳清的特征,并确定负责其抑制作用的成分.

主要方法:

用MFGM丰富的乳清,乳清蛋白分离物 (WPI) 和乳清蛋白缩物 (WPC) 用特定细胞系对轮状病毒,RSV和SARS-CoV-2进行了测试.
通过测量病毒感染力来评估抗病毒活性.
使用LC-MS/MS和31P-NMR分析了蛋白质和脂组成.

主要成果:

用MFGM丰富的乳清证明了对轮状病毒和RSV的剂量依赖抑制,在高度下部分抑制了SARS-CoV-2.
与对照组相比,蛋白质组分析显示,在富含MFGM的乳清中,特定的MFGM蛋白质和其他抗病毒蛋白质的丰富.
用MFGM丰富的乳清表现出最高水平的特定和总脂.

结论:

富含MFGM的乳清对临床意义上的病毒具有广泛的抗病毒活性.
该研究阐明了MFGM丰富乳清中的活性成分,支持其在减少婴儿感染方面的潜在作用.

关键词:

更多关于 MFGM 的文章这就是为什么RSV RSV.这就是SARS-CoV-2病毒.牛奶牛奶牛奶牛奶轮状病毒病毒的病毒.

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