摄入原水解剂后生物活性的吸收:在健康个体中进行的一项随机双盲交叉研究
Nicolina Virgilio1, Christiane Schön2, Yvonne Mödinger2
1Rousselot BV, Ghent, Belgium.
Frontiers in nutrition
|August 16, 2024
概括
来自各种来源和分子量的原化物 (CH) 显示了与氧 (Hyp) 的可比吸收. 这表明,CH有效地提供含有Hyp的,支持它们在功能性食品中的生物可用性.
科学领域:
- 营养生物化学 营养生物化学
- 药理动力学 药理动力学
- 食品科学 食品科学 食品科学
背景情况:
- 原化物 (CH) 是功能性食品和补充剂的关键成分,提供氨基酸 (AAs) 和.
- 人们已经认识到CH具有潜在的健康益处,因此需要进行生物可用性研究.
- 这项研究的重点是来自不同分子重量的鱼,猪和牛来源的皮肤和皮肤衍生CH.
研究的目的:
- 评估一次剂量的原化物生物可用性.
- 为了比较来自不同动物来源 (鱼,猪,牛) 的CH的吸收.
- 评估分子量 (2,000 和 5,000 Da) 对CH生物可用性的影响.
主要方法:
- 一项随机,双盲,交叉临床研究与健康的志愿者进行.
- 测量了自由和与结合的氧素 (Hyp) 的血度.
- 量化了特定的原衍生,以评估吸收.
主要成果:
- 所有测试的原化物都显示出可比的自由氧的吸收.
- 与自由Hyp相比,总Hyp的升高水平表明含有Hyp的二和三的显著吸收.
- CH的来源和分子量并没有阻碍关键代谢物的血度.
结论:
- 来自不同来源和分子重量的原解液被有效吸收.
- 这项研究证实了CH的氧和相关的生物可用性.
- 需要进一步的研究来确定生理效应的最佳代谢物水平.
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