具有精神生物特性的乳球球菌株可以改善老年小鼠的认知和情绪变化
Kan Gao1,2,3, Cailing Chen1,2,3, Zhiyao Zheng1,2,3
1Research and Development Department, Hangzhou Wahaha Group Co., Ltd., Hangzhou, China.
Frontiers in nutrition
|August 16, 2024
概括
两种特定的乳球球菌亲生菌株L. lactis WHH2078和L. cremoris WHH2080被发现可以改善老年小鼠的认知和情绪功能. 这些益生菌积极调节肠道微生物群和5-HTP代谢,为与年龄相关的疾病提供了潜在的可能性.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 衰老与认知和情绪障碍有关.
- 益生菌,特别是乳球菌株,通过肠道微生物群-大脑轴 (GBA) 减轻这些与年龄相关的功能障碍.
- 两种乳球菌株L. lactis WHH2078和L. cremoris WHH2080此前已被鉴定为它们增强5-基酸 (5-HTP) 分泌的能力.
研究的目的:
- 调查L. lactis WHH2078和L. cremoris WHH2080对老年小鼠认知和情绪障碍的影响.
- 探索涉及5-HT代谢和肠道微生物群调节的潜在机制.
- 评估这些益生菌菌株对与年龄相关的神经和情绪障碍的治疗潜力.
主要方法:
- 年龄较大的小鼠每天口服L. lactis WHH2078和L. cremoris WHH2080持续12周.
- 认知,类似抑郁和类似焦虑的行为被评估.
- 分析了海马神经元完整性,5-HT代谢和神经炎症.
- 血清代谢学发现了托代谢的变化.
- 用16S rRNA测序分析了肠道微生物社区的组成.
主要成果:
- 在老年小鼠中,口服WHH2078和WHH2080显著改善了认知功能,并减少了类似抑郁和焦虑的行为.
- 益生菌恢复了神经元的损失,使5-HT代谢正常化,并减少了海马体中的神经炎症.
- 代谢分析显示,托代谢受损的反转,包括5-HT和5-HTP水平的正常化.
- 肠道微生物群分析显示,关键细菌群的恢复,包括减少Firmicutes和增加Bacteroidota.
- 这些有益影响与5HT代谢和肠道微生物组成的调节相关.
结论:
- 乳球菌 WHH2078和乳球菌 WHH2080在改善老年相关认知和情绪缺陷方面表现出显著的有效性.
- 这些益生菌菌株通过调节肠道微生物群-大脑轴来发挥作用,特别是影响托代谢并减少神经炎症.
- 这些发现支持这些促进5-HTP的乳球球菌株作为治疗年龄相关认知和情绪障碍的新治疗策略的潜力.
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