美国成年人血清维生素A度与病毒性肝炎之间的关联来自NHANES数据库:一个横截面研究
Maoxia Liu1, Jianlei Fu1, Xuepeng Zhang1
1Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
Frontiers in nutrition
|August 16, 2024
概括
这项研究发现,B型肝炎 (HBsAg) 或C型肝炎 (HCV-RNA) 感染的个体往往具有较低的维生素A (VA) 水平. 这些患者中亚临床维生素A缺乏症 (SVAD) 较为常见,这表明病毒性肝炎和维生素A状况之间存在联系.
科学领域:
- 营养生物化学 营养生物化学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 维生素A (VA) 水平与肝炎病毒携带之间的关联仍然不清楚和有争议.
- 了解这种关系对于潜在的临床干预至关重要.
研究的目的:
- 调查血清VA水平与病毒性肝炎 (乙型肝炎和乙型肝炎) 之间的潜在关系.
- 为未来与病毒性肝炎和维生素A状况相关的临床治疗提供见解.
主要方法:
- 使用NHANES数据集 (2005-2006年和2017-2018年) 的横截面研究.
- 分析HBsAg/HCV-RNA阳性和血清VA水平之间的关联,使用多重线性和逻辑回归.
- 包括5351名与HBsAg相关的和242名与HCV-RNA相关的反应者.
主要成果:
- 与负面受访者相比,HBsAg (+) 和HCV-RNA (+) 受访者显示血清VA水平明显较低 (P <0.001).
- 与正常VA (VAN) 组相比,亚临床VA缺乏 (SVAD) 组中HBsAg (+) 和HCV-RNA (+) 个体的患病率较高 (分别为p=0.003和p=0.043).
- 血清VA度与HBsAg (+) 和HCV-RNA (+) 状态负相关 (分别为p=0.066和p=0.005). 与SVAD患者相比,VAN患者的HBsAg (+) 或HCV-RNA (+) 的可能性较小 (分别为p=0.089和p=0.016).
结论:
- 具有HBsAg或HCV-RNA阳性的患者表现出亚临床维生素A缺乏症 (SVAD) 的高发病率.
- B型肝炎和C型肝炎病毒的阳性与血清VA水平有负相关.
- 建议进行进一步的基础研究和大规模临床试验,以验证这些发现并探索新的治疗点.
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