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偏氧酶1-108C/T多态和冠心病之间的关联:更新的元分析

Jiadan Liao¹, Pengcheng Wang²

¹Department of Cardiology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in cardiovascular medicine

|August 16, 2024

概括

偏氧酶1 (PON1) -108T等位基因是冠状动脉心脏病 (CHD) 的潜在危险因素. 这一元分析表明,PON1-108C/T多态性和心血管疾病易感性增加之间存在联系.

科学领域:

遗传学是一个遗传学.
心血管疾病流行病学
生物标志物生物标志物

背景情况:

偏氧酶1 (PON1) -108C/T多态和冠心病 (CHD) 易感性之间的关联缺乏明确的共识.
现有研究提出了关于PON1遗传变异在心脏病风险中的作用的矛盾结果.

研究的目的:

进行现有研究的综合元分析,以澄清PON1 -108C/T多态和CHD易感性之间的关系.
提供关于PON1变异对心血管疾病风险的遗传贡献的综合观点.

主要方法:

系统地搜索电子数据库,查找调查PON1 -108C/T多态和CHD的病例控制研究.
使用Stata 12.0进行元分析,以计算赔率比率 (OR) 和95%置信区间 (CI).
包括13项病例控制研究,包括2979例病例和2887例对照.

主要成果:

在各种遗传模型中,PON1 -108C/T多态性与心血管疾病易感性有显著的关联 (例如,T与C:OR=1.24,95%CI1.07-1.45).
亚组分析表明,种族和样本大小没有影响观察到的结果.
生物信息学分析表明,108C>T多态影响PON1基因表达.

结论:

确定PON1 -108T等位基因是冠状动脉心脏病 (CHD) 的潜在低透风险因素.
这一元分析支持PON1 -108C/T多态性和患心脏病的风险增加之间的遗传联系.

关键词:

-108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C/T -108C 一个叫PON1的人.冠心病是一种冠心病.这是一个元分析.危险的风险危险的风险

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